Chromosomal damage in human lymphocytes from radio-isotope therapy.

Chromosomal damage in human lymphocytes from radio-isotope therapy.

Variablity of chromosomal radioadaptive response in human lymphocytes.

Background : There are growing evidences for chromosomal radioadaptive response in human lymphocytes . Highly variable inter- and intra-individual responses have been reported. Some individuals are non-responders and even in some donors the frequency of chromatid aberrations induced by a challenge dose increases by pre-exposure to an adapting dose. It has been proposed that the lack of radioada...

variablity of chromosomal radioadaptive response in human lymphocytes.

background : there are growing evidences for chromosomal radioadaptive response in human lymphocytes . highly variable inter- and intra-individual responses have been reported. some individuals are non-responders and even in some donors the frequency of chromatid aberrations induced by a challenge dose increases by pre-exposure to an adapting dose. it has been proposed that the lack of radioada...

Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures.

AIMS We evaluated whether radiation exposure during interventional cardiovascular procedures can induce damage to deoxyribonucleic acid (DNA). METHODS AND RESULTS Micronucleus assay (MN) was performed as biomarker of chromosomal damage and intermediate endpoint in carcinogenesis. Seventy-two patients (54 males, age = 63.8 +/- 10.5 years) undergoing a wide range of radiation exposure during in...

Induction of Chromosomal Damages in Lymphocytes Induced by Radiopaque Substances

The iodinated radiopaques are widely used in radiologicals procedures for their higher quality and for better pathological diagnosis. Since they are numerous and can lead to cellular toxicity and/or genotoxicity, this study was carried out to investigate the efficacy of two routine compounds, that is, urographin 76% and telbrix 38. For this purpose, the metaphasic chromosomes of 30 patients un...